I had a chat this morning with my oncologist Doctor Zeigler about the DFMO preventative trials.
He raised some concerns about the science behind this, in particular
-
There were no mouse models ran, he is running one at the moment
-
From our trials he expected DFMO only to be effective at higher doses in combination with chemo
-
The current trial is not a double blind study, it is very hard to interpret results
-
Only results published to date were for phase 1 trials
We started using DFMO at SCH for relapse treatment (in combination with chemo) Dr. Zeigler’s goal is to bring it into frontline chemo, so its an extra drug you take during induction for high risk NB.
The good news is that nobody seems concerned about the safety of the trial, only concern is around efficacy of it.
I am still, very much looking forward to the results that are to be published in 2 months, hoping they give us more information.
@birdni you seem to be quite across a lot of the science around NB any feedback on the DFMO trials?